Cerebral Vein Thrombosis

Cerebral venous thrombosis is a rare neonatal condition with an incidence of up to 6.4 per 100,000 infants and a mortality rate nearly double that of older children. It encompasses thrombosis of the dural venous sinuses as well as the cerebral veins, often with multivessel involvement. Neonates are particularly susceptible due to an immature hemostatic system, with major risk factors, including congenital heart disease, complicated delivery, hypoxia, and sepsis. Clinical presentation is often nonspecific; however, seizures are the most common manifestation. Cranial ultrasonography with Doppler is the preferred initial imaging modality, while MRI with MR venography is the diagnostic standard for defining thrombus extent and associated parenchymal injury.