Journal of Pediatric Case Reports

Hirschsprung Disease

Journal of Pediatric Case Reports

Published January 29, 2026

DOI: 10.37549/JPCR-25-0063

Tayler D. Mackie, BS1, Richard B. Towbin, MD2, Carrie M. Schaefer, MD2, Alexander J. Towbin, MD3

1 Texas Tech University Health Sciences Center El Paso, El Paso, Texas

2 Department of Radiology, Phoenix Children’s Hospital, Phoenix, Arizona

3 Department of Radiology, Children’s Hospital of Cincinnati, University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

Contrast enema is the primary modality for diagnosing Hirschsprung’s disease in the neonate. The most common findings on imaging are a rectosigmoid transitional zone, an abnormal rectosigmoid index, and a saw-tooth pattern depicting impaired peristalsis. The absence of a transitional zone in the neonate may observed due to immature bowel. A suction rectal biopsy is the gold standard to confirm the diagnosis.

Keywords: Gastrointestinal, Congenital, Colon

Citation

Mackie TD, Towbin RB, Schaefer CM, Towbin AJ. Hirschsprung Disease. Journal of Pediatric Case Reports. 2026. doi:10.37549/JPCR-25-0063.

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