Pulmonary Interstitial Glycogenosis

Pulmonary interstitial glycogenosis (PIG) is a rare interstitial lung disease that presents in neonates with rapidly progressive respiratory distress. Because there are no specific clinical, radiologic, or genetic markers for the disease, diagnosis relies on lung biopsy. Prognosis depends on disease context: isolated PIG is typically associated with favorable outcomes, whereas cases with concurrent pulmonary or cardiovascular abnormalities may have a more complicated clinical course. Treatment generally includes corticosteroids and supportive care, tailored to the severity of respiratory symptoms and any underlying conditions.